Proof of Concept / Medical Affairs & KOL Strategy
KOL Influence
Network
A graph analytics engine mapping key opinion leader influence networks in IDH-mutant cholangiocarcinoma. This proof of concept applies PageRank, betweenness centrality, and Louvain community detection to a synthetic network of 120 KOLs — computing influence scores, identifying community structure, and rendering an interactive force-directed visualization entirely in-browser with no backend dependencies.
Disclaimer: This is a proof-of-concept demonstration using entirely synthetic data. All KOL names, institutional affiliations, publication counts, prescribing volumes, and network relationships are algorithmically generated and do not represent actual physicians, researchers, or institutions. This tool is NOT intended for commercial KOL engagement planning and should NOT inform actual Medical Affairs strategies.
Generating KOL network & computing graph metrics...
Technical Architecture
Graph Algorithms
PageRank computes global recursive influence using 50 iterations with 0.85 damping. Betweenness centrality is approximated via sampled BFS from 30 source nodes to maintain O(n*m) complexity. Composite scores blend PageRank (40%), degree (30%), and betweenness (30%).
Community Detection
Greedy modularity optimization inspired by the Louvain method. Iteratively moves nodes between communities to maximize Q, the ratio of within-community edge density to expected density under a null model. Converges in under 10 passes for networks of this scale.
Force-Directed Layout
Fruchterman-Reingold force-directed placement with 150 iterations and simulated annealing. Repulsive forces between all node pairs and attractive forces along edges produce spatial clustering that mirrors community structure. Seeded PRNG ensures deterministic output.
References
- Razumilava N, Gores GJ. Cholangiocarcinoma. Lancet. 2014;383(9935):2168-2179.
- Borger DR, et al. Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. Oncologist. 2012;17(1):72-79.
- Abou-Alfa GK, et al. Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study. Lancet Oncol. 2020;21(6):796-807.
- Blondel VD, et al. Fast unfolding of communities in large networks. J Stat Mech. 2008;2008(10):P10008.
- Page L, et al. The PageRank citation ranking: bringing order to the web. Stanford InfoLab Technical Report. 1999.
- Fruchterman TMJ, Reingold EM. Graph drawing by force-directed placement. Software Pract Exp. 1991;21(11):1129-1164.