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Proof of Concept / Gradient Boosting Regression

Launch Uptake Curve
Predictor

Gradient Boosting on Historical Oncology Launch Analogues

A gradient boosting regression model trained on 20 synthetic oncology launch analogues to predict a new product's market share trajectory over 24 months. Features include clinical evidence strength, market structure, access barriers, and commercial execution — with bootstrap confidence intervals and analogue-based benchmarking. Built entirely in-browser.

Gradient BoostingLaunch AnaloguesBootstrap CISensitivity AnalysisCosine SimilarityUptake Modeling

Disclaimer: This is a proof-of-concept using synthetic launch data and fictional product names. All market share projections, launch characteristics, and analogue profiles are illustrative. This tool is NOT intended for actual commercial forecasting or investment decisions.

Generating historical analogues & training gradient boosting model...

Technical Architecture

Analogue-Based Regression

Training data generated from 20 synthetic oncology launches using logistic growth curves with feature-dependent parameters. Each analogue contributes 24 monthly observations, yielding 480 training samples across 11 feature dimensions (10 launch features + month number).

Bootstrap Confidence Intervals

10 gradient boosting models trained on resampled analogue sets. For each prediction month, the 2.5th and 97.5th percentile of ensemble predictions define the 95% confidence band, capturing model uncertainty due to limited training data.

Cosine Similarity Matching

Feature vectors min-max normalized across all analogues, then compared via cosine similarity. Top matches serve as intuitive benchmarks — showing the user which historical launches most closely resemble their configured scenario.

References

  • Friedman JH. Greedy function approximation: a gradient boosting machine. Annals of Statistics. 2001;29(5):1189-1232.
  • Aitken M, Kleinrock M. Global oncology trends 2024. IQVIA Institute for Human Data Science. 2024.
  • Efron B, Tibshirani R. An Introduction to the Bootstrap. Chapman & Hall/CRC; 1993.
  • Garau M, et al. Uptake patterns of new oncology drugs: a retrospective analysis. Value in Health. 2020;23(S1):S178.

Daniel Tran, PharmD

UC San Diego — Skaggs School of Pharmacy

Source code MIT. Content © 2026 Daniel Tran (CC BY-NC-SA 4.0).